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Women's health innovation, South Africa

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South Africa

South Africa has one of Africa's most developed health-tech ecosystems and a mature market for sexual and reproductive health, anchored by the government's flagship MomConnect maternal mHealth service and a heavy public HIV/SRH burden concentrated among young women. Its femtech startup scene remains small but growing, led by Johannesburg's Zoie Health, while gender-lens funds and continental platforms such as UNICEF Femtech Ventures increasingly target the country. Landmark policy shifts, including the 2024 National Health Insurance Act and a national SRHR policy, are reshaping how women's health is financed and delivered.

Maternal & digital healthReproductive health & rightsHIV/SRH for womenFemtech startupsUniversal health coverage
~4.7M mothers

Registered on MomConnect maternal mHealth platform since 2014 health.gov.za

118 per 100,000

Maternal mortality ratio (2023), still above SDG target of 70 data.worldbank.org

68,813 births

Births to teenage girls at SA health facilities in 2024 citizen.co.za

~15.9% CAGR

Projected SA femtech market growth 2025-2030 grandviewresearch.com

01 of 07

Latest major news

Recent developments span funding platforms, HIV prevention finance, and encouraging shifts in adolescent and maternal health data.

02 of 07

Policy & strategy

South Africa combines one of the world's most liberal abortion laws with an ambitious universal-coverage and digital-health agenda.

03 of 07

Latest ecosystem moves

New funds, catalytic platforms and government digital-health rollouts are reshaping the women's health landscape.

04 of 07

Notable funding rounds

Disclosed femtech rounds remain scarce; Kasha's SA-expansion Series B is the largest, with most local deals undisclosed pre-seed rounds or equity-free grants.

05 of 07

Key players & hubs

The ecosystem spans a handful of femtech startups, government mHealth programmes, world-class research institutes and major SRH NGOs.

06 of 07

Active investors

Gender-lens funds, impact investors and multilateral financiers underpin SA's women's health and femtech activity.

07 of 07

White papers & reports

Key reports track maternal mortality, adolescent pregnancy trends, abortion access and femtech market outlook.

Latest major news

2026-05
UNICEF Femtech Ventures activated its first cohort of 11 startups (from 1,100+ applications across 85 countries), convened in Pretoria, each receiving up to USD 100,000 equity-free.
disruptafrica.com
2026-04
Public-sector data showed teen pregnancies dropped 16 percent across all nine provinces between April 2021 and March 2025, with births to girls aged 10 to 14 falling nearly 40 percent.
ewn.co.za
2025-12
Five35 Ventures, a female-focused pan-African VC and Kasha co-investor, secured an anchor investment from the Mastercard Foundation Africa Growth Fund to expand its women-focused portfolio.
techcabal.com
2025-03
The Global Fund, with PEPFAR, CIFF and the Gates Foundation, moved to roll out twice-yearly injectable lenacapavir HIV prevention for around 2 million people, a priority for young women.
bhekisisa.org
2025-01
A US executive order froze PEPFAR funding (roughly USD 400M+/year to SA HIV programmes) for a 90-day review; adolescent girls and women flagged among the first affected.
phr.org
2024-02
Reporting highlighted that women-led African health-tech firms, including SA's Zoie Health, secured USD 52M in funding, a 2,000 percent-plus increase.
forbesafrica.com

Policy & strategy

2024-05
President Ramaphosa signed the National Health Insurance (NHI) Act No. 20 of 2023 into law, launching a phased path to universal health coverage with women cited as direct beneficiaries.
gov.za
2021-01
The National Integrated Sexual and Reproductive Health and Rights (SRHR) Policy, Edition 1, set a rights-based framework covering contraception, fertility treatment and safe abortion care.
knowledgehub.health.gov.za
2019-01
The National Digital Health Strategy for South Africa 2019-2024 set a vision of better health enabled by digital health, prioritising scale-up of mHealth like MomConnect.
knowledgehub.health.gov.za
2019-06
Revised National Contraception Clinical Guidelines expanded the method mix, including the Implanon NXT subdermal implant and the female condom.
pmc.ncbi.nlm.nih.gov
1996-01
The Choice on Termination of Pregnancy Act legalised abortion on request up to 12 weeks, among the most liberal abortion laws globally; clinical guideline last updated 2021.
health.gov.za

Latest ecosystem moves

â–¸UNICEF Femtech Ventures, a five-year (2025-2030) platform backed by Sweden and Temasek Foundation, hosted its inaugural cohort in Pretoria, offering up to USD 100,000 equity-free per startup. unicef.org
â–¸SA impact investor E Squared deployed over R300M into startups in 2025 (R1.37bn lifetime across 227 ventures), including femtech via its Zoie Health participation. techinafrica.com
â–¸The SAMRC and PATH launched a Global Health Innovation Accelerator (GHIA) for medical devices, diagnostics and tools serving vulnerable women and children. path.org
â–¸Startupbootcamp AfriTech co-runs a USD 7M healthtech project (with Salient Advisory and SCIDaR), supported by the Gates Foundation, backing African digital-health startups. startupbootcamp.org
â–¸The National Department of Health began beta rollout of the e-Impilo national electronic medical record in primary care facilities in 2025, using biometric patient identification. theglobalfund.org

Notable funding rounds

Disclosed round size (USD)

Kasha USD 21M
Series B · 2023-07 · Knife Capital techcabal.com
Zoie Health undisclosed
Pre-seed extension · 2023-06 · 4DX Ventures ventureburn.com
Zoie Health USD 20K (grant)
Grant · 2023-01 · UNDP Meet the Toshikas undp.org
Aviro Health undisclosed
Pre-Series A · 2021-09 · ASISA ESD Fund (Edge Growth) ventureburn.com
UNICEF Femtech Ventures cohort up to USD 100K each
Grant (equity-free) · 2026-05 · Government of Sweden / Temasek Foundation femtechinsider.com
Five35 Ventures undisclosed (anchor)
Fund anchor · 2025-12 · Mastercard Foundation Africa Growth Fund engineeringnews.co.za

Rounds by type

6 rounds
Series B1
Pre-seed extension1
Grant1
Pre-Series A1
Grant (equity-free)1
Fund anchor1

Key players & hubs

Ecosystem by organisation type

13 orgs
Startup4
NGO4
Govt3
Hub2
Zoie Health
Startup

Johannesburg Black woman-led digital women's health clinic: virtual consults, medication subscriptions, family planning, fertility and maternity techcabal.com

Kasha
Startup

Women-focused digital retail and last-mile delivery of sanitary products, contraceptives and pharmaceuticals; operates in South Africa itweb.co.za

Aviro Health
Startup

Cape Town healthtech; Aviro Pocket Clinic offers digital HIV and SRH counselling and decision-support for providers avirohealth.com

Femmflo
Startup

South Africa's first hormone and mental-health app with in-lab and at-home testing builtinafrica.io

Oky South Africa
NGO

Period-tracking app for young girls, launched by loveLife and UNICEF; zero-rated and multilingual okyapp.info

MomConnect (Dept of Health)
Govt

National maternal mHealth service via SMS and WhatsApp in all 11 official languages; ~4.7M mothers registered health.gov.za

National Department of Health
Govt

Runs SRHR policy, MomConnect, HPV vaccination and Saving Mothers confidential enquiries knowledgehub.health.gov.za

Wits RHI
NGO

Wits Reproductive Health and HIV Institute; leading African research institute on HIV, SRH and PrEP trials across all nine provinces wrhi.ac.za

SAMRC
Govt

South African Medical Research Council; largest local health-research funder with a Gender and Health Research Unit samrc.ac.za

MSI Reproductive Choices South Africa
NGO

Largest non-profit provider of abortion and SRH care in South Africa (formerly Marie Stopes) msichoices.org

loveLife
NGO

Youth SRH/HIV NGO (founded 1999) reducing new HIV infections and unplanned pregnancies among 15-24 year-olds lovelife.org.za

Startupbootcamp AfriTech
Hub

Cape Town pan-African accelerator with a healthtech track and Gates-supported digital-health programme sbcafritech.com

Founders Factory Africa
Hub

Johannesburg early-stage investor and accelerator with a broad healthtech portfolio; USD 114M raised foundersfactory.africa

Active investors

Active investors by headquarters

USA 4
South Africa 3
Mauritius 1
Switzerland 1
Enygma Ventures
First VC fund solely for female entrepreneurs in the SADC region; invested USD 3.5M across 10 businesses including in South Africa ventureburn.com
USA
4DX Ventures
Led Zoie Health's pre-seed extension round f4.fund
USA
E Squared Investments
Impact investor (Allan Gray); participated in Zoie Health pre-seed extension; R300M+ deployed in 2025 esquared.org.za
South Africa
Knife Capital
Led Kasha's USD 21M Series B funding SA expansion of women's health commerce techcabal.com
South Africa
Five35 Ventures
Female-focused seed/Series A VC; Kasha co-investor; anchored by Mastercard Foundation in 2025 five35.ventures
Mauritius
Dazzle Angels
First female-focused angel network in SA; interests include healthcare and maternal/child health dazzleangels.com
South Africa
Global Fund
Major multilateral financier of SA HIV programmes; co-funding injectable lenacapavir rollout unaids.org
Switzerland
PEPFAR (US)
Bilateral funder of SA HIV programmes (~USD 400M+/year); funding under review from Jan 2025 phr.org
USA
Gates Foundation
Co-funds lenacapavir HIV rollout and backs the SBC AfriTech healthtech project startupbootcamp.org
USA

White papers & reports

â–¸Saving Mothers 2020-2022, Eighth Comprehensive Triennial Report on Confidential Enquiries into Maternal Deaths (National Department of Health) health.gov.za
â–¸Declining adolescent pregnancies in South Africa: insights from public sector data 2021-2025 (Spotlight) spotlightnsp.co.za
â–¸Abortion providers as human rights defenders: policy priorities for South Africa (Frontiers in Reproductive Health, 2025) frontiersin.org
â–¸South Africa Femtech Market Outlook to 2030 (Grand View Research) grandviewresearch.com

Sources and references

Every figure and claim above links back to a public source. 17 references, updated 2026-08.